We only spent one night at Destino Sur, after hiking to Laguna de Los Tres - yes, the long, yet epic and not to be missed hike. It was welcoming, clean and the room was spacious for the 3 of us. We walked to dinner to a perfect spot, so no need for transportation. Beds were comfortable - but would have liked a softer pillow!
Breakfast in the morning (included) was everything you'd want. Service very accommodating. Someone shared with us that it is 'the best' hotel in Chalten. Certainly served us just fine.