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Exterior & Views 1, Holiday Inn Express & Suites ST. LOUIS SOUTH - I-55 by IHG, Saint Louis
Exterior & Views 2, Holiday Inn Express & Suites ST. LOUIS SOUTH - I-55 by IHG, Saint Louis
Food & Drinks 3, Holiday Inn Express & Suites ST. LOUIS SOUTH - I-55 by IHG, Saint Louis
Sport & Beauty 4, Holiday Inn Express & Suites ST. LOUIS SOUTH - I-55 by IHG, Saint Louis
Bedroom 5, Holiday Inn Express & Suites ST. LOUIS SOUTH - I-55 by IHG, Saint Louis
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Hotel

Holiday Inn Express & Suites ST. LOUIS SOUTH - I-55 by IHG

Saint Louis, Missouri

The Fun Awaits

Suitable for your business trip
Suitable for your business tripStay productive with business facilities.

Reviews

See all
4.8/5
FantasticFrom 200 reviews
5.0/57 Oct 2025
John C
Staff was amazing
5.0/57 Oct 2025
John C
Staff was amazing
5.0/528 Sep 2025
Jacob
Very safe, quiet, clean, and the staff were amazing. Ill definitely be back!
5.0/528 Sep 2025
Jacob
Very safe, quiet, clean, and the staff were amazing. Ill definitely be back!
5.0/526 Sep 2025
Diane
Parking was easy and secure.
5.0/526 Sep 2025
Diane
Parking was easy and secure.
5.0/521 Sep 2025
Danielle
My stay was awesome! Everything was great! Staff so awesome! Friendliest hotel I’ve ever stayed at! A+
5.0/521 Sep 2025
Danielle
My stay was awesome! Everything was great! Staff so awesome! Friendliest hotel I’ve ever stayed at! A+
5.0/519 Sep 2025
Linhan
good
5.0/519 Sep 2025
Linhan
good
5.0/55 Sep 2025
Marilyn
My family and I were in transit to a family reunion in Wisconsin. We had double reservations here and back. Both times were very satisfying and great. Amazing breakfast and love cookie hour.
5.0/55 Sep 2025
Marilyn
My family and I were in transit to a family reunion in Wisconsin. We had double reservations here and back. Both times were very satisfying and great. Amazing breakfast and love cookie hour.
5.0/529 Aug 2025
Verified traveler
The girls at the front desk were very friendly. The nightly milk & cookies were a big hit!
5.0/529 Aug 2025
Verified traveler
The girls at the front desk were very friendly. The nightly milk & cookies were a big hit!
5.0/529 Aug 2025
Marilyn
We are currently still checked in and had the most delicious & well presented breakfast. Coffee is excellent, and breakfast area is cleaned. The breakfast server was very friendly & respectful.
5.0/529 Aug 2025
Marilyn
We are currently still checked in and had the most delicious & well presented breakfast. Coffee is excellent, and breakfast area is cleaned. The breakfast server was very friendly & respectful.
5.0/519 Aug 2025
Cresley • Family Trip
I have stayed at this property multiple times and it’s always a good experience. The staff are friendly and do an excellent job at keeping up the facility. I look forward to returning.
5.0/519 Aug 2025
Cresley • Family Trip
I have stayed at this property multiple times and it’s always a good experience. The staff are friendly and do an excellent job at keeping up the facility. I look forward to returning.
5.0/515 Aug 2025
Tameka • Family Trip
Great stay and clean hotel. I had a double queen and the room was very spacious. Great breakfast option and friendly staff.
5.0/515 Aug 2025
Tameka • Family Trip
Great stay and clean hotel. I had a double queen and the room was very spacious. Great breakfast option and friendly staff.

Location

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4250 Midamerica Lane, 63129
All distances are measured in straight lines. The actual travel distance may be different.

Accommodation Rules

Check-in Procedure
Check-in14:00-23:59
Check-out11:00

  • Extra-person charges may apply and vary depending on property policy
  • Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
  • Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
  • This property accepts credit cards; cash is not accepted
  • Safety features at this property include a fire extinguisher
  • This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)

Front desk staff will greet guests on arrival at the property. Information provided by the property may be translated using automated translation tools.

See more

Want to check in early? Fill out the Special Requests form on the booking page.

More Policies

Children

Guests of all ages are welcome to stay.

Children ages 12 years old and above will be considered as adults.

Please make sure that the children’s age is consistent with the information listed on your booking details. Otherwise, you may have to pay additional fees upon check-in.


Deposit

Guests no need to pay a deposit at check-in.


Age

Guests of all ages are welcome to stay.


Breakfast

Breakfast is available from 06:30 - 10:00 local time.


Pets

No pets allowed.


Smoking

No smoking room.


Alcohol

Alcohol drinks allowed.


About Holiday Inn Express & Suites ST. LOUIS SOUTH - I-55 by IHG

Welcome to the new Holiday Inn Express & Suites St. Louis South I-55! South St. Louis's newest and most modern Holiday Inn Express Hotel nestled within a growing development at the intersection of Butler Hill Road & I-55 just one mile south of I-270/255 with access to everything St. Louis has to offer. The hotel is just 14 miles directly south of Downtown St. Louis and located at exit #195 from I-55. Business travelers will benefit from our central location with easy on/off access to I-55 that offers access to the different areas of St. Louis within minutes. The hotel complex includes the Barnes-Jewish Siteman Cancer Center & Mercy Health. We are just minutes from Metlife, Anhueser Busch, Cigna and the National Cemetary Association. Our non smoking Holiday Inn Express & Suites St. Louis I-55 hotel is very convenient to guests visiting Busch Stadium, Gateway Arch, Grant's Farm, Magic House, St. Louis Science Center, St. Louis Zoo, Forest Park, River City Casino and much more!Hotel Guests can enjoy an array of amenities including guest room suites, Indoor Pool, Suite Shop, Two Meeting Rooms, Complimentary Express Start Breakfast, Complimentary High Speed Wired & Wireless Internet, Comfortable Great Room with Outdoor Patio and warm Cookies & Milk served nightly. Guests will enjoy our midwest hospitality in South St. Louis. Our goal is to make every guest feel at home so that we exceed all of their expectations!

Room Type and Price

Sun, 15 Nov 2026 - Mon, 16 Nov 2026 (1 night)
1 Room, 1 Adult, 0 Children