Showing 13 hotels in Cape Girardeau













Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO Location
With a stay at Drury Inn & Suites Jackson MO, you'll be centrally located in Jackson, within a 10-minute drive of Cape Girardeau Conservation Nature Center and Saint Francis Healthcare System. This hotel is 10.2 mi (16.5 km) from Mississippi River and 10.4 mi (16.7 km) from Shawnee National Forest.
Drury Inn & Suites Jackson MO Facility and Service
Take advantage of recreational opportunities offered, including an indoor pool, a hot tub, and a fitness center. Additional features at this hotel include complimentary wireless internet access, a television in a common area, and a banquet hall.
Drury Inn & Suites Jackson MO Rooms
Make yourself at home in one of the 80 guestrooms featuring refrigerators and microwaves. LCD televisions with cable programming provide entertainment, while complimentary wireless internet access keeps you connected. Private bathrooms with shower/tub combinations feature complimentary toiletries and hair dryers. Conveniences include desks and separate sitting areas, as well as phones with free local calls.
Restaurant and Cafe
Meet other guests and eat at the complimentary reception. A complimentary buffet breakfast is served on weekdays from 6:00 AM to 9:00 AM and on weekends from 7:00 AM to 10:00 AM.
See detailsWith a stay at Drury Inn & Suites Jackson MO, you'll be centrally located in Jackson, within a 10-minute drive of Cape Girardeau Conservation Nature Center and Saint Francis Healthcare System. This hotel is 10.2 mi (16.5 km) from Mississippi River and 10.4 mi (16.7 km) from Shawnee National Forest.
Drury Inn & Suites Jackson MO Facility and Service
Take advantage of recreational opportunities offered, including an indoor pool, a hot tub, and a fitness center. Additional features at this hotel include complimentary wireless internet access, a television in a common area, and a banquet hall.
Drury Inn & Suites Jackson MO Rooms
Make yourself at home in one of the 80 guestrooms featuring refrigerators and microwaves. LCD televisions with cable programming provide entertainment, while complimentary wireless internet access keeps you connected. Private bathrooms with shower/tub combinations feature complimentary toiletries and hair dryers. Conveniences include desks and separate sitting areas, as well as phones with free local calls.
Restaurant and Cafe
Meet other guests and eat at the complimentary reception. A complimentary buffet breakfast is served on weekdays from 6:00 AM to 9:00 AM and on weekends from 7:00 AM to 10:00 AM.
“Great deal”

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau Location
With a stay at Drury Inn & Suites Cape Girardeau, you'll be centrally located in Cape Girardeau, within a 10-minute drive of Shawnee National Forest and Mississippi River. This hotel is 1.2 mi (2 km) from Saint Francis Medical Center and 2.7 mi (4.3 km) from Saint Francis Healthcare System.
Drury Inn & Suites Cape Girardeau Facility and Service
Be sure to enjoy recreational amenities, including an indoor pool, a hot tub, and a fitness center. Additional features at this hotel include complimentary wireless internet access, a television in a common area, and a banquet hall.
Drury Inn & Suites Cape Girardeau Rooms
Make yourself at home in one of the 87 guestrooms featuring refrigerators and LCD televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Private bathrooms with shower/tub combinations feature complimentary toiletries and hair dryers. Conveniences include desks and separate sitting areas, as well as phones with free local calls.
Restaurant and Cafe
Meet other guests and eat at the complimentary reception. A complimentary buffet breakfast is served on weekdays from 6:00 AM to 9:00 AM and on weekends from 7:00 AM to 10:00 AM.
See detailsWith a stay at Drury Inn & Suites Cape Girardeau, you'll be centrally located in Cape Girardeau, within a 10-minute drive of Shawnee National Forest and Mississippi River. This hotel is 1.2 mi (2 km) from Saint Francis Medical Center and 2.7 mi (4.3 km) from Saint Francis Healthcare System.
Drury Inn & Suites Cape Girardeau Facility and Service
Be sure to enjoy recreational amenities, including an indoor pool, a hot tub, and a fitness center. Additional features at this hotel include complimentary wireless internet access, a television in a common area, and a banquet hall.
Drury Inn & Suites Cape Girardeau Rooms
Make yourself at home in one of the 87 guestrooms featuring refrigerators and LCD televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Private bathrooms with shower/tub combinations feature complimentary toiletries and hair dryers. Conveniences include desks and separate sitting areas, as well as phones with free local calls.
Restaurant and Cafe
Meet other guests and eat at the complimentary reception. A complimentary buffet breakfast is served on weekdays from 6:00 AM to 9:00 AM and on weekends from 7:00 AM to 10:00 AM.
“Great deal”

Courtyard By Marriott Cape Girardeau Downtown
Experience the character of a thoughtfully restored property at our hotel in downtown Cape Girardeau, where historic charm blends seamlessly with modern comfort. Our Cape Girardeau, MO hotel places you steps from local restaurants, unique bars, and cultural destinations, along with convenient access to the Southeast Missouri State University campus. You can start or end your day at The Bistro, offering balanced breakfast and dinner options alongside a full bar featuring a curated bourbon selection. After exploring the neighborhood, retreat to well‑designed guest rooms and suites with plush bedding and city views that create a relaxing space to unwind. A spacious 24‑hour fitness center helps you stay on track with your routine. Our family friendly hotel in downtown Cape Girardeau, will be loved by adults and children of all ages. The property also provides versatile event space ideal for small to mid‑sized meetings. Your stay at Courtyard Cape Girardeau Downtown is crafted for comfort and ease.
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Hampton Inn Cape Girardeau I-55 East
incredible service at our Cape Girardeau, MO hotel. From our daily free hot breakfast to our nightly cookie hour, Hampton Inn Cape Girardeau I-55 East makes you feel at home. Located on the southeast corner of I-55 and William Street, our hotel complex includes various shopping and dining options. Walk to seven restaurants within the complex such as Cracker Barrel, Texas Roadhouse and Panera Bread. This beautiful new hotel offers all the amenities you need while traveling. Start your day with a quick workout in the fitness room or with some laps in the heated indoor pool. Sit down to a free, hot breakfast served daily with items including fresh baked waffles, eggs, biscuits and gravy and rotating options. If you’re pressed for time, grab Hampton’s On the Run™ Breakfast Bags, available Monday through Friday. Stay connected to the office with free WiFi in every room or work in the business center with two computer terminals and printing capabilities. End your day at our nightly cookie hour with warm cookies, cold milk and friendly team members available for your questions or concerns. Rest comfortably on a clean and fresh Hampton bed® watching the 37-inch HDTV or with your laptop on the provided lap desk.
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Pear Tree Inn Cape Girardeau Near The Medical Cen
Ideally located in the prime touristic area of Cape Girardeau, Pear Tree Inn Cape Girardeau Near the Medical Cent promises a relaxing and wonderful visit. Featuring a complete list of amenities, guests will find their stay at the property a comfortable one. Free Wi-Fi in all rooms, 24-hour front desk, facilities for disabled guests, luggage storage, Wi-Fi in public areas are just some of the facilities on offer. Comfortable guestrooms ensure a good night's sleep with some rooms featuring facilities such as television LCD/plasma screen, internet access – wireless, internet access – wireless (complimentary), air conditioning, heating. The hotel offers various recreational opportunities. For reliable service and professional staff, Pear Tree Inn Cape Girardeau Near the Medical Cent caters to your needs.
See details“Worth it”

Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau Downtown Location
Located in Cape Girardeau, Courtyard by Marriott Cape Girardeau Downtown is within a 15-minute walk of Southeast Missouri State University and eDen Spa & Salon. This hotel is 0.5 mi (0.7 km) from Shawnee National Forest and 0.6 mi (1 km) from Century Casino & Hotel Cape Girardeau.
Courtyard by Marriott Cape Girardeau Downtown Facility and Service
Take advantage of recreation opportunities such as a 24-hour fitness center or take in the view from a terrace and a garden. This hotel also features complimentary wireless internet access and gift shops/newsstands.
Courtyard by Marriott Cape Girardeau Downtown Rooms
Make yourself at home in one of the 91 guestrooms featuring refrigerators. Your bed comes with down comforters and Egyptian cotton sheets. Complimentary wired and wireless internet access keeps you connected, and satellite programming provides entertainment. Private bathrooms with bathtubs or showers feature complimentary toiletries and hair dryers.
Restaurant and Cafe
Satisfy your appetite with American cuisine at The Bistro, a bistro which features a bar/lounge. Dining is also available at the coffee shop/cafe. Cooked-to-order breakfasts are served on weekdays from 6:30 AM to 9:30 AM and on weekends from 7:00 AM to 10:00 AM for a fee.
See detailsLocated in Cape Girardeau, Courtyard by Marriott Cape Girardeau Downtown is within a 15-minute walk of Southeast Missouri State University and eDen Spa & Salon. This hotel is 0.5 mi (0.7 km) from Shawnee National Forest and 0.6 mi (1 km) from Century Casino & Hotel Cape Girardeau.
Courtyard by Marriott Cape Girardeau Downtown Facility and Service
Take advantage of recreation opportunities such as a 24-hour fitness center or take in the view from a terrace and a garden. This hotel also features complimentary wireless internet access and gift shops/newsstands.
Courtyard by Marriott Cape Girardeau Downtown Rooms
Make yourself at home in one of the 91 guestrooms featuring refrigerators. Your bed comes with down comforters and Egyptian cotton sheets. Complimentary wired and wireless internet access keeps you connected, and satellite programming provides entertainment. Private bathrooms with bathtubs or showers feature complimentary toiletries and hair dryers.
Restaurant and Cafe
Satisfy your appetite with American cuisine at The Bistro, a bistro which features a bar/lounge. Dining is also available at the coffee shop/cafe. Cooked-to-order breakfasts are served on weekdays from 6:30 AM to 9:30 AM and on weekends from 7:00 AM to 10:00 AM for a fee.
“Great deal”

Comfort Suites Jackson-Cape Girardeau
The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Get more of the space you need to spread out, relax or work at the smoke-free Comfort Suites Jackson-Cape Girardeau hotel in Jackson, MO off Interstate 55. Nearby destinations include Southeast Missouri State University, Shawnee Park Sports Complex, Riverfront Park of Cape Girardeau, Trail of Tears State Park and Southeast Missouri Hospital. Enjoy amenities like free hot breakfast, free WiFi, fitness center, business center and indoor heated pool. Spacious suites include HDTV, refrigerator, microwave, hair dryer, sofa sleeper and recharge device. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.
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La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Location
When you stay at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau in Jackson, you'll be in the business district, within a 15-minute drive of Shawnee National Forest and Mississippi River. This hotel is 1.5 mi (2.3 km) from Cape Girardeau Conservation Nature Center and 2.7 mi (4.4 km) from Saint Francis Healthcare System.
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Facility and Service
Don't miss out on recreational opportunities including an indoor pool and a 24-hour fitness center. This hotel also features complimentary wireless internet access, a banquet hall, and a vending machine.
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Rooms
Make yourself at home in one of the 80 air-conditioned rooms featuring refrigerators and microwaves. 49-inch LED televisions with cable programming provide entertainment, while complimentary wireless internet access keeps you connected. Bathrooms feature bathtubs or showers, complimentary toiletries, and hair dryers. Conveniences include desks and coffee/tea makers, as well as phones with free local calls.
Restaurant and Cafe
Grab a bite from the snack bar/deli, or stay in and take advantage of the hotel's room service (during limited hours). A complimentary self-serve breakfast is served on weekdays from 6:00 AM to 9:00 AM and on weekends from 6:00 AM to 10:00 AM.
See detailsWhen you stay at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau in Jackson, you'll be in the business district, within a 15-minute drive of Shawnee National Forest and Mississippi River. This hotel is 1.5 mi (2.3 km) from Cape Girardeau Conservation Nature Center and 2.7 mi (4.4 km) from Saint Francis Healthcare System.
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Facility and Service
Don't miss out on recreational opportunities including an indoor pool and a 24-hour fitness center. This hotel also features complimentary wireless internet access, a banquet hall, and a vending machine.
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Rooms
Make yourself at home in one of the 80 air-conditioned rooms featuring refrigerators and microwaves. 49-inch LED televisions with cable programming provide entertainment, while complimentary wireless internet access keeps you connected. Bathrooms feature bathtubs or showers, complimentary toiletries, and hair dryers. Conveniences include desks and coffee/tea makers, as well as phones with free local calls.
Restaurant and Cafe
Grab a bite from the snack bar/deli, or stay in and take advantage of the hotel's room service (during limited hours). A complimentary self-serve breakfast is served on weekdays from 6:00 AM to 9:00 AM and on weekends from 6:00 AM to 10:00 AM.
“Worth it”

Quality Inn Cape Girardeau
The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Get more for your money at the Quality Inn and Suites hotel in Vacaville, CA. Our convenient location near I-80, between Sacramento and San Francisco, makes this hotel your ideal lodging destination when traveling for business or pleasure. For your convenience, our business center offers access to copy and fax services. Guest laundry facilities are available, too. We also have ample parking for buses and trucks. Additional must-have amenities include free WiFi, grab and go breakfast, outdoor pool and a spa. We invite you to relax in your guest room, which features a refrigerator, microwave, coffee maker, hair dryer, iron and ironing board.
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Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center Location
When you stay at Drury Plaza Hotel Cape Girardeau Conference Center in Cape Girardeau, you'll be connected to the convention center, within a 10-minute drive of Shawnee National Forest and Mississippi River. This hotel is 0.7 mi (1.1 km) from Saint Francis Medical Center and 2.2 mi (3.5 km) from Saint Francis Healthcare System.
Drury Plaza Hotel Cape Girardeau Conference Center Facility and Service
Be sure to enjoy recreational amenities, including an indoor pool, a hot tub, and a fitness center. This hotel also features complimentary wireless internet access and a banquet hall.
Drury Plaza Hotel Cape Girardeau Conference Center Rooms
Make yourself at home in one of the 168 guestrooms featuring refrigerators and microwaves. 43-inch LCD televisions with cable programming provide entertainment, while complimentary wireless internet access keeps you connected. Bathrooms have shower/tub combinations and hair dryers. Conveniences include desks and separate sitting areas, as well as phones with free local calls.
Restaurant and Cafe
Enjoy a satisfying meal at The Southerner serving guests of Drury Plaza Hotel Cape Girardeau Conference Center. Mingle with other guests at the complimentary reception, held daily. A complimentary buffet breakfast is served on weekdays from 6:00 AM to 9:00 AM and on weekends from 7:00 AM to 10:00 AM.
See detailsWhen you stay at Drury Plaza Hotel Cape Girardeau Conference Center in Cape Girardeau, you'll be connected to the convention center, within a 10-minute drive of Shawnee National Forest and Mississippi River. This hotel is 0.7 mi (1.1 km) from Saint Francis Medical Center and 2.2 mi (3.5 km) from Saint Francis Healthcare System.
Drury Plaza Hotel Cape Girardeau Conference Center Facility and Service
Be sure to enjoy recreational amenities, including an indoor pool, a hot tub, and a fitness center. This hotel also features complimentary wireless internet access and a banquet hall.
Drury Plaza Hotel Cape Girardeau Conference Center Rooms
Make yourself at home in one of the 168 guestrooms featuring refrigerators and microwaves. 43-inch LCD televisions with cable programming provide entertainment, while complimentary wireless internet access keeps you connected. Bathrooms have shower/tub combinations and hair dryers. Conveniences include desks and separate sitting areas, as well as phones with free local calls.
Restaurant and Cafe
Enjoy a satisfying meal at The Southerner serving guests of Drury Plaza Hotel Cape Girardeau Conference Center. Mingle with other guests at the complimentary reception, held daily. A complimentary buffet breakfast is served on weekdays from 6:00 AM to 9:00 AM and on weekends from 7:00 AM to 10:00 AM.
“Great deal”

Jackson Town House Inn
Town House Inn

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau Location
With a stay at Fairfield Inn & Suites by Marriott Cape Girardeau in Cape Girardeau, you'll be within a 10-minute drive of Shawnee National Forest and Mississippi River. This hotel is 1.2 mi (1.9 km) from Saint Francis Medical Center and 2.8 mi (4.5 km) from Southeast Missouri Hospital.
Fairfield Inn & Suites by Marriott Cape Girardeau Facility and Service
Don't miss out on recreational opportunities including an indoor pool and a 24-hour fitness center.
Fairfield Inn & Suites by Marriott Cape Girardeau Rooms
Make yourself at home in one of the 103 air-conditioned rooms featuring kitchenettes. Wired and wireless internet access is complimentary, while 55-inch flat-screen televisions with satellite programming provide entertainment. Conveniences include desks and microwaves, as well as phones with free local calls.
Restaurant and Cafe
A complimentary continental breakfast is served daily.
See detailsWith a stay at Fairfield Inn & Suites by Marriott Cape Girardeau in Cape Girardeau, you'll be within a 10-minute drive of Shawnee National Forest and Mississippi River. This hotel is 1.2 mi (1.9 km) from Saint Francis Medical Center and 2.8 mi (4.5 km) from Southeast Missouri Hospital.
Fairfield Inn & Suites by Marriott Cape Girardeau Facility and Service
Don't miss out on recreational opportunities including an indoor pool and a 24-hour fitness center.
Fairfield Inn & Suites by Marriott Cape Girardeau Rooms
Make yourself at home in one of the 103 air-conditioned rooms featuring kitchenettes. Wired and wireless internet access is complimentary, while 55-inch flat-screen televisions with satellite programming provide entertainment. Conveniences include desks and microwaves, as well as phones with free local calls.
Restaurant and Cafe
A complimentary continental breakfast is served daily.

Tru by Hilton Cape Girardeau
From our daily free hot breakfast to our nightly cookie hour, Tru Cape Girardeau makes you feel at home. Located just off Interstate 55 at exit 99, we are conveniently located near the Cape Girardeau Sportsplex, Southeast Missouri State University, and the Conservation Nature Center. This beautiful hotel offers all the amenities you need while traveling. Start your day with a quick workout in the fitness center or with some laps in the heated indoor pool. Sit down to a free, hot breakfast served daily with items including fresh-baked waffles, eggs, biscuits and gravy, and rotating options. Stay connected to the office with free Wi-Fi in every room or work from one of our quaint business nooks located in the lobby. End your day at our nightly cookie hour with warm cookies, cold milk, and friendly team members available for your questions or concerns.
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